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CCR8 Protein

CCR8 Spezies: Human Wirt: Mammalian Cells MSP Nanodisc
Produktnummer ABIN7538187
  • Target Alle CCR8 Proteine anzeigen
    CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))
    Protein-Typ
    MSP Nanodisc
    Spezies
    • 8
    • 2
    • 2
    Human
    Quelle
    • 7
    • 2
    • 2
    • 1
    Mammalian Cells
    Verwendungszweck
    Human CCR8 full length protein membrane nanoparticles (MNPs)
    Produktmerkmale
    Plasma membrane-coated nanoparticles (MNPs) have been used in various applications, including delivery of therapeutic agents and induction of immune responses et al. Unlike the conventional strategies, MNPs directly leverage intact and natural functions of cell membranes, and show high biocompatibility, specificity, and low side effects. Our optimized MNPs platform for the full-length membrane protein production uses membrane coating technology and a HEK293 based expression platform. The high-purity plasma membrane-coated nanoparticles were produced by extrusion after membrane extraction from the host HEK293 cells containing the overexpressed target proteins.
    Top Product
    Discover our top product CCR8 Protein
  • Kommentare

    Advantages of Membrane Nanoparticles (MNPs):

    • High display density of target membrane proteins
    • Native structure and orientation of transmembrane protein
    • soluble in aqueous solutions for routine biochemical analysis
    • Detergent-free purification process
    • Strong immunogenicity
    • Works for MPs that can´t be produced via VLPs and EXos
    Limitations of Membrane Nanoparticles (MNPs):
    • Lack of accurate quantification of the target membrane proteins.
    • Need to develop special SPR assayx.
    • Cell membranes contain housekeeping proteins that can result in immune response dilution.
    • Some membrane proteins can´t be enriched on membrane.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))
    Andere Bezeichnung
    CCR8 (CCR8 Produkte)
    Synonyme
    CC-CKR-8 Protein, CCR-8 Protein, CDw198 Protein, CKRL1 Protein, CMKBR8 Protein, CMKBRL2 Protein, CY6 Protein, GPRCY6 Protein, TER1 Protein, C-C Protein, C-C CKR-8 Protein, CKR-8 Protein, Cmkbr8 Protein, mCCR8 Protein, C-C motif chemokine receptor 8 Protein, chemokine (C-C motif) receptor 8 Protein, CCR8 Protein, Ccr8 Protein
    Hintergrund
    A member of the beta chemokine receptor family,which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309,thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically,this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.
    Molekulargewicht
    The human full length CCR8 Protein has a MW of 40.7 kDa
    UniProt
    P51685
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