F2RL2 Protein

Produktnummer ABIN7538199

Produktdetails

Target: F2RL2 (Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2))

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human PAR3 full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: F2RL2 (Coagulation Factor II (thrombin) Receptor-Like 2 (F2RL2))

Andere Bezeichnung: PAR3 (F2RL2 Produkte)

Synonyme: PAR-3 Protein, PAR3 Protein, par3 Protein, Cf-2 Protein, Cf2 Protein, FII Protein, thrombin Protein, F730031A08 Protein, f2 Protein, f2rl2 Protein, coagulation factor II thrombin receptor like 2 Protein, coagulation factor II (thrombin) receptor-like 2 Protein, coagulation factor II Protein, coagulation factor II, thrombin Protein, coagulation factor II, thrombin L homeolog Protein, coagulation factor II (thrombin) receptor-like 2 L homeolog Protein, F2RL2 Protein, f2rl2 Protein, F2 Protein, F2rl2 Protein, f2.L Protein, f2rl2.L Protein

Hintergrund: This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012]

Molekulargewicht: The human full length PAR3 protein has a MW of 42.5kDa

UniProt: O00254

Pathways: Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling