Complement Factor I Protein (CFI) (AA 19-583) (His tag)

Produktnummer ABIN7538205

Produktdetails

Target: Complement Factor I (CFI)

Protein-Typ: Recombinant

Proteineigenschaft: AA 19-583

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses Complement Factor I Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human CFI Protein with C-terminal 6xHis tag

Spezifität: CFI (Lys19-Val583) 6xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Complement Factor I (CFI)

Andere Bezeichnung: CFI (CFI Produkte)

Synonyme: cfi Protein, MGC53615 Protein, Cfi Protein, factor I Protein, IF Protein, gb:ai721528 Protein, ahus3 Protein, c3b-ina Protein, c3bc4bi Protein, c3bina Protein, kaf Protein, CFI Protein, AHUS3 Protein, C3BINA Protein, C3b-INA Protein, FI Protein, KAF Protein, complement factor I S homeolog Protein, complement factor I L homeolog Protein, complement factor I Protein, complement component factor i Protein, cfi.S Protein, cfi.L Protein, CFI Protein, cfi Protein, Cfi Protein

Hintergrund: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015]

Molekulargewicht: predicted molecular mass of 64.3 kDa after removal of the signal peptide. The apparent molecular mass of CFI-His is 70-100 kDa due to glycosylation.

UniProt: P05156

Pathways: Komplementsystem