FZD2 Protein

Produktnummer ABIN7538244

Produktdetails

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human FZD2 full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: FZD2 (Frizzled Family Receptor 2 (FZD2))

Andere Bezeichnung: FZD2 (FZD2 Produkte)

Synonyme: BG01711 Protein, CG9739 Protein, D-Fz2 Protein, D-fz2 Protein, DFZ2 Protein, DFz-2 Protein, DFz2 Protein, Dfrz2 Protein, Dfz2 Protein, Dfz[[2]] Protein, Dm Fz2 Protein, Dmel\\CG9739 Protein, FZ2 Protein, Fz2 Protein, dFz2 Protein, dfz(2) Protein, dfz2 Protein, dfz2r Protein, frz2 Protein, fz-2 Protein, fz8 Protein, zfz2 Protein, zg08 Protein, cb383 Protein, wu:fb70g09 Protein, FZD2 Protein, fzE2 Protein, hFz2 Protein, Fz-10 Protein, Fzd10 Protein, cFz-2 Protein, frizzled2 Protein, fz2 Protein, xfz2 Protein, AL033370 Protein, AW456835 Protein, Fz10 Protein, Mfz10 Protein, Mfz10a Protein, frizzled 2 Protein, frizzled class receptor 2 Protein, frizzled class receptor 2 S homeolog Protein, fz2 Protein, fzd2 Protein, FZD2 Protein, Fzd2 Protein, fzd2.S Protein

Hintergrund: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

Molekulargewicht: The human full length FZD2 protein has a MW of 63.6kDa

UniProt: Q14332

Pathways: WNT Signalweg