G Protein-Coupled Receptor 12 Protein (GPR12)

Produktnummer ABIN7538253

Produktdetails

Target: G Protein-Coupled Receptor 12 (GPR12)

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human GPR12 full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: G Protein-Coupled Receptor 12 (GPR12)

Andere Bezeichnung: GPR12 (GPR12 Produkte)

Synonyme: GPCR12 Protein, GPCR21 Protein, Gpcr12 Protein, Gpcr01 Protein, Gpcr20 Protein, Gpcr21 Protein, G protein-coupled receptor 12 Protein, G-protein coupled receptor 12 Protein, GPR12 Protein, Gpr12 Protein

Hintergrund: Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.[UniProtKB/Swiss-Prot Function]

Molekulargewicht: The human full length GPR12 protein has a MW of 36.7kDa

UniProt: P47775