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HRH1 Protein

HRH1 Spezies: Human Wirt: Mammalian Cells Synthetic Nanodisc
Produktnummer ABIN7538319
  • Target Alle HRH1 Proteine anzeigen
    HRH1 (Histamine Receptor H1 (HRH1))
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 5
    • 2
    • 1
    Human
    Quelle
    • 3
    • 3
    • 2
    Mammalian Cells
    Verwendungszweck
    Human HRH1 full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product HRH1 Protein
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    HRH1 (Histamine Receptor H1 (HRH1))
    Andere Bezeichnung
    HRH1 (HRH1 Produkte)
    Synonyme
    H1-R Protein, hisH1 Protein, Bphs Protein, H1R Protein, HH1R Protein, Hir Protein, HRH1 Protein, H1 Protein, Hisr Protein, histamine receptor H1 Protein, histamine receptor H 1 Protein, HRH1 Protein, Hrh1 Protein, hrh1 Protein
    Hintergrund
    Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
    Molekulargewicht
    The human full length HRH1 protein has a MW of 55.8kDa
    UniProt
    P35367
    Pathways
    Regulation of Carbohydrate Metabolic Process
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