LILRB4 Protein (AA 22-259) (Fc Tag)

Produktnummer ABIN7538355

Produktdetails

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Protein-Typ: Recombinant

Proteineigenschaft: AA 22-259

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses LILRB4 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human LILRB4 Protein with C-terminal human Fc tag

Spezifität: LILRB4 (Gln22-Glu259) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: LILRB4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 4 (LILRB4))

Andere Bezeichnung: LILRB4 (LILRB4 Produkte)

Synonyme: CD85K Protein, ILT-3 Protein, ILT3 Protein, LIR-5 Protein, LIR5 Protein, Gp49b Protein, HM18 Protein, gp49 Protein, leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 Protein, leukocyte immunoglobulin like receptor B4 Protein, leukocyte immunoglobulin-like receptor, subfamily B, member 4A Protein, LILRB4 Protein, Lilrb4a Protein

Hintergrund: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Molekulargewicht: predicted molecular mass of 52.4 kDa after removal of the signal peptide. The apparent molecular mass of LILRB4-hFc is 55-70 kDa due to glycosylation.

UniProt: Q8NHJ6