MCHR1 Protein

Produktnummer ABIN7538380

Produktdetails

Target: MCHR1 (Melanin-Concentrating Hormone Receptor 1 (MCHR1))

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human MCHR1 full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: MCHR1 (Melanin-Concentrating Hormone Receptor 1 (MCHR1))

Andere Bezeichnung: MCHR1 (MCHR1 Produkte)

Synonyme: GPR24 Protein, MCH-1R Protein, MCH1R Protein, SLC-1 Protein, SLC1 Protein, AW049955 Protein, Gpr24 Protein, Mch1r Protein, Mch-1r Protein, Slc1 Protein, MCH-R1 Protein, MCHR1 Protein, melanin concentrating hormone receptor 1 Protein, melanin-concentrating hormone receptor 1 Protein, MCHR1 Protein, Mchr1 Protein

Hintergrund: The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

Molekulargewicht: The human full length MCHR1 protein has a MW of 46kDa

UniProt: Q99705

Pathways: Feeding Behaviour