c-MET Protein (AA 25-932) (His tag)

Produktnummer ABIN7538393

Produktdetails

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Protein-Typ: Recombinant

Proteineigenschaft: AA 25-932

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses c-MET Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human MET Protein with C-terminal 10xHis tag

Spezifität: MET (Glu25-Thr932) 10xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Andere Bezeichnung: MET (MET Produkte)

Synonyme: AUTS9 Protein, HGFR Protein, RCCP2 Protein, c-Met Protein, AI838057 Protein, HGF Protein, Par4 Protein, Hgfr Protein, c-met Protein, MET Protein, C-MET Protein, met Protein, met-A Protein, MET proto-oncogene, receptor tyrosine kinase Protein, met proto-oncogene Protein, MET proto-oncogene, receptor tyrosine kinase L homeolog Protein, MET Protein, Met Protein, met.L Protein

Hintergrund: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Molekulargewicht: predicted molecular mass of 103.0 kDa after removal of the signal peptide. The apparent molecular mass of MET-His is 70-130 kDa due to glycosylation.

UniProt: P08581

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor