MUC16 Protein (AA 13810-14451) (His tag)

Produktnummer ABIN7538396

Produktdetails

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Protein-Typ: Recombinant

Proteineigenschaft: AA 13810-14451

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses MUC16 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant human MUC16(13810-14451) Protein with C-terminal 10xHis tag

Spezifität: MUC16 (Pro13810-Pro14451) 10xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: MUC16 (CA125 Produkte)

Synonyme: CA125 Protein, 1110008I14Rik Protein, Ca125 Protein, Gm1480 Protein, RGD1308422 Protein, MUC16 Protein, mucin 16, cell surface associated Protein, mucin 16 Protein, mucin-16 Protein, MUC16 Protein, Muc16 Protein, LOC476718 Protein, LOC712735 Protein

Hintergrund: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

Molekulargewicht: predicted molecular mass of 73.2 kDa after removal of the signal peptide. The apparent molecular mass of MUC16(13810-14451)-His is 100-130 kDa due to glycosylation.

UniProt: Q8WXI7