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OPN4 Protein

OPN4 Spezies: Human Wirt: Mammalian Cells Synthetic Nanodisc
Produktnummer ABIN7538460
  • Target Alle OPN4 Proteine anzeigen
    OPN4 (Opsin 4 (OPN4))
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 1
    • 1
    Human
    Quelle
    • 2
    Mammalian Cells
    Verwendungszweck
    Human OPN4 full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    OPN4 (Opsin 4 (OPN4))
    Andere Bezeichnung
    OPN4 (OPN4 Produkte)
    Synonyme
    MOP Protein, 1110007J02Rik Protein, Gm533 Protein, OPN4-2 Protein, cOpn4L Protein, melanopsin Protein, opn4-A Protein, Xmop Protein, opn4 Protein, opn4d Protein, opsin 4 Protein, opsin 4 (melanopsin) Protein, melanopsin Protein, melanopsin-B-like L homeolog Protein, opsin 4a (melanopsin) Protein, OPN4 Protein, Opn4 Protein, LOC100303707 Protein, LOC100485437.L Protein, opn4a Protein
    Hintergrund
    Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Molekulargewicht
    The human full length OPN4 protein has a MW of 52.6kDa
    UniProt
    Q9UHM6
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