RAMP1 Protein (AA 27-117) (mFc Tag)

Produktnummer ABIN7538505

Produktdetails

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-117

Spezies: Human

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses RAMP1 Protein ist gelabelt mit mFc Tag.

Verwendungszweck: Recombinant human RAMP1 Protein with C-terminal mouse Fc tag

Spezifität: RAMP1 (Cys27-Ser117) mFc (Pro99-Lys330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1 (RAMP1))

Andere Bezeichnung: RAMP1 (RAMP1 Produkte)

Synonyme: RAMP1 Protein, MGC147096 Protein, 9130218E19Rik Protein, receptor activity modifying protein 1 Protein, receptor (G protein-coupled) activity modifying protein 1 Protein, receptor (calcitonin) activity modifying protein 1 Protein, RAMP1 Protein, ramp1 Protein, Ramp1 Protein

Hintergrund: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Molekulargewicht: predicted molecular mass of 36.7 kDa after removal of the signal peptide. The apparent molecular mass of RAMP1-mFc is 35-55 kDa due to glycosylation.

UniProt: O60894

Pathways: cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process