SELPLG Protein (AA 34-356) (His tag)

Produktnummer ABIN7538516

Produktdetails

Target: SELPLG (Selectin P Ligand (SELPLG))

Protein-Typ: Recombinant

Proteineigenschaft: AA 34-356

Spezies: Cynomolgus

Quelle: Mammalian Cells

Aufreinigungstag / Konjugat: Dieses SELPLG Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Cynomolgus SELPLG protein with C-terminal 6xHis tag

Spezifität: SELPLG (Leu34-Cys356) 6xHis tag

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: SELPLG (Selectin P Ligand (SELPLG))

Andere Bezeichnung: SELPLG (SELPLG Produkte)

Synonyme: CD162 Protein, CLA Protein, PSGL-1 Protein, PSGL1 Protein, SELPLG Protein, SELPG Protein, Psgl-1 Protein, Psgl1 Protein, Selp1 Protein, Selpl Protein, selectin P ligand Protein, selectin, platelet (p-selectin) ligand Protein, clasper Protein, SELPLG Protein, Selplg Protein, cla Protein

Hintergrund: This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Molekulargewicht: predicted molecular mass of 34.3 kDa after removal of the signal peptide.

UniProt: A0A7N9CVJ8