Serotonin Receptor 1A Protein (HTR1A)

Produktnummer ABIN7538518

Produktdetails

Target: Serotonin Receptor 1A (HTR1A)

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human 5HT1A full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Serotonin Receptor 1A (HTR1A)

Andere Bezeichnung: 5HT1A (HTR1A Produkte)

Synonyme: 5-HT-dro2A Protein, 5-HT1ADro Protein, 5-HT[1A]Dro Protein, 5-HT[[1ADro]] Protein, 5-HT[[1A]] Protein, 5-HT[[1A]]DRO Protein, 5HT-R2A Protein, 5HT-dro2A Protein, 5HT-drp[[2A]] Protein, 5HT1A Protein, 5HT[[1ADro]] Protein, 5htdro2a Protein, CG16720 Protein, DRO2A Protein, Dm5HTdro2A Protein, Dmel\\CG16720 Protein, d5-HT1A Protein, 5htr1a Protein, htr1a Protein, HTR1A Protein, Htr1a Protein, 5-Ht1a Protein, Gpcr18 Protein, 5-HT-1A Protein, 5-HT1A Protein, 5HT1a Protein, ADRB2RL1 Protein, ADRBRL1 Protein, G-21 Protein, PFMCD Protein, RAT5HT1A Protein, 5ht1a Protein, adrb2rl1 Protein, adrbrl1 Protein, htr1a-A Protein, 5-hydroxytryptamine (serotonin) receptor 1A Protein, 5-hydroxytryptamine receptor 1A Protein, 5-hydroxytryptamine (serotonin) receptor 1A a Protein, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog Protein, 5-HT1A Protein, HTR1A Protein, htr1aa Protein, Htr1a Protein, htr1a.L Protein

Hintergrund: This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Molekulargewicht: The human full length 5HT1A protein has a MW of 46.1kDa

UniProt: P08908

Pathways: JAK-STAT Signalweg, Synaptic Membrane, Feeding Behaviour