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Serotonin Receptor 2B Protein (HTR2B)

HTR2B Spezies: Human Wirt: Mammalian Cells Synthetic Nanodisc
Produktnummer ABIN7538522
  • Target Alle Serotonin Receptor 2B (HTR2B) Proteine anzeigen
    Serotonin Receptor 2B (HTR2B)
    Protein-Typ
    Synthetic Nanodisc
    Spezies
    • 5
    • 1
    • 1
    Human
    Quelle
    • 4
    • 2
    • 1
    Mammalian Cells
    Verwendungszweck
    Human 5HT2B full length protein-synthetic nanodisc
    Produktmerkmale
    Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
    Top Product
    Discover our top product HTR2B Protein
  • Kommentare

    Advantages of Synthetic Nanodiscs:

    • Highly purified membrane proteins
    • High solubility in aqueous solutions
    • High stability
    • Proteins are in a native membrane environment and remain biologically active
    • No detergent and can be used for cell-based assays
    • No MSP backbone proteins
    Limitations of Synthetic Nanodiscs:
    • Intolerant to acids and high concentrations of divalent metal ions

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
    Haltbarkeit
    12 months
  • Target
    Serotonin Receptor 2B (HTR2B)
    Andere Bezeichnung
    5HT2B (HTR2B Produkte)
    Synonyme
    5-HT2B Protein, 5HT2B Protein, 5htr2b Protein, HTR2B Protein, 5ht2b Protein, zgc:194094 Protein, zgc:194119 Protein, AJ012488 Protein, AV377389 Protein, 5-HT(2B) Protein, 5-hydroxytryptamine receptor 2B Protein, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Protein, 5-hydroxytryptamine (serotonin) receptor 2B Protein, HTR2B Protein, htr2b Protein, Htr2b Protein
    Hintergrund
    This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
    Molekulargewicht
    The human full length 5HT2B protein has a MW of 54.3kDa
    UniProt
    P41595
    Pathways
    JAK-STAT Signalweg, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process
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