Serotonin Receptor 5A Protein (HTR5A)

Produktnummer ABIN7538524

Produktdetails

Target: Serotonin Receptor 5A (HTR5A)

Protein-Typ: Synthetic Nanodisc

Spezies: Human

Quelle: Mammalian Cells

Verwendungszweck: Human 5HT5A full length protein-synthetic nanodisc

Produktmerkmale: Unlike other membrane scaffold protein (MSP) Nanodisc on the market, our synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.

Anwendungsinformationen

Kommentare:

Advantages of Synthetic Nanodiscs:

• Highly purified membrane proteins
• High solubility in aqueous solutions
• High stability
• Proteins are in a native membrane environment and remain biologically active
• No detergent and can be used for cell-based assays
• No MSP backbone proteins

Limitations of Synthetic Nanodiscs:

• Intolerant to acids and high concentrations of divalent metal ions

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: Serotonin Receptor 5A (HTR5A)

Andere Bezeichnung: 5HT5A (HTR5A Produkte)

Synonyme: HTR5A Protein, si:dkey-265a7.5 Protein, Htr5 Protein, 5-HT5A Protein, 5HT5A Protein, MR22 Protein, 5-hydroxytryptamine receptor 5A Protein, 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate a Protein, 5-hydroxytryptamine (serotonin) receptor 5A Protein, HTR5A Protein, htr5aa Protein, Htr5a Protein

Hintergrund: The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2 mobilization. [provided by RefSeq, Jul 2008]

Molekulargewicht: The human full length 5HT5A protein has a MW of 40.3kDa

UniProt: P47898

Pathways: JAK-STAT Signalweg