Caspase 2 Protein

Produktnummer ABIN925026

Produktdetails

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ~10,000 units/mg. One unit cleaves 1nmole of the caspase substrate VDVAD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with PBS to 1 unit/µl.

Lagerung: -80 °C

Antigendetails

Target: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Andere Bezeichnung: Caspase-2 (CASP2 Produkte)

Synonyme: xCaspase-2 Protein, Caspase-2 Protein, ICH-1 Protein, Nedd2 Protein, CASP-2 Protein, ICH1 Protein, NEDD-2 Protein, NEDD2 Protein, PPP1R57 Protein, ICH-1L/1S Protein, ICH1L1S Protein, caspase 2 Protein, caspase 2 L homeolog Protein, caspase-2 Protein, CASP2 Protein, casp2.L Protein, CpipJ_CPIJ008254 Protein, Casp2 Protein

Hintergrund: Caspase-2 (also known as Ich-1, Nedd-2) is a member of the interleukin-1 converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-2 also exists in cells as an inactive proenzyme. During apoptosis, procaspase-2 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-2 consists of large (19 kDa) and small (12 kDa) subunits, which associate to form the active enzyme. The active recombinant human caspase-2 was expressed in E. coli. The expressed caspase-2 spontaneously undergoes auto-processing to yield the subunits characteristic of the native enzyme.

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Neurotrophin Signalübertragung