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TPMT Protein (AA 1-245)

TPMT Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % pure SDS
Produktnummer ABIN934951
  • Target Alle TPMT Proteine anzeigen
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-245
    Spezies
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 12
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Applikation
    SDS-PAGE (SDS)
    Sequenz
    MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP HAEIERLFGK ICNIRRLEKV DAFEERHKSW GIDCLFEKLY LLTEK
    Produktmerkmale
    Purified recombinant Human TPMT protein
    Expression System: E.coli
    Molecular weight on SDS-PAGE will appear higher.
    Reinheit
    > 95 % pure
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    Discover our top product TPMT Protein
  • Applikationshinweise
    TPMT protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Supplied as a liquid in 20 mM Tris, pH 8.0, containing 0.0 mM PMSF, and 0 mM EDTA.
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    RT/-20 °C
    Informationen zur Lagerung
    Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
  • Target
    TPMT (Thiopurine S-Methyltransferase (TPMT))
    Andere Bezeichnung
    TPMT (TPMT Produkte)
    Hintergrund
    TPMT, thiopurine S-methyltransferase, is a cytosolic enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine and azathioprine are used as chemotherapeutic agents. TPMT activity exhibits autosomal codominant genetic polymorphism, and patients inheriting TPMT-deficiency are at high risk of potentially fatal hematopoietic toxicity. Recombinant human TPMT was expressed in E. coli and purified by using conventional chromatography techniques.
    Alternative Names: Thiopurine methyltransferase protein, Thiopurine S methyltransferase., Thiopurine S-methyltransferase HGNC:12014 protein, Thiopurine S-methyltransferase protein, TPMT protein, S adenosyl L methionine thiopurine S methyltransferase protein
    Molekulargewicht
    28 kDa (245 AA)
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