TANK Protein (AA 1-119)

Produktnummer ABIN935032

Produktdetails

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-119

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Sequenz: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI

Produktmerkmale: Purified recombinant Human TANK protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher.

Reinheit: > 90 % pure

Anwendungsinformationen

Applikationshinweise: TANK protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.

Antigendetails

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Andere Bezeichnung: TANK (TANK Produkte)

Hintergrund: TANK, also known as TRAF(tumor necrosis factor receptor-associated Factor)-interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. Recombinant human TANK protein was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: TRAF interacting protein TANK isoform b protein, TRAF interacting protein protein, TRAF family member associated NFKB activator protein, TRAF2 protein, I-TRAF protein, TRAF interacting protein TANK isoform a, ITRAF protein, TRAF family member associated NF KAPPA B activator protein, TRAF interacting protein TANK isoform b I TRAF protein

Molekulargewicht: 13.6 kDa (119 AA)

Pathways: p53 Signalweg, TLR Signalweg, Activation of Innate immune Response