Visinin-like protein-1, also known as VILIP-1, belongs to a family of neuronal calcium sensor proteins. VILIP-1 is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Also, it is expressed in pancreatic beta-cells. VILIP-1 elevation enhances insulin secretion in cAMP-associated manner. Down-regulation of VILIP-1 decreased cAMP accumulation but increased insulin gene transcription. Recombinant human Visinin-like protein-1 was expressed in E. coli and purified by using conventional chromatography. Alternative Names: Neurocalcin alpha protein, Visinin.Visinin like 1 protein, HLP3 protein, NVL1 protein, Visininlike 1, HLP 3 protein, Visinin like protein 1.VISL 1., NVL 1 protein, VILIP-1 protein, VILIP protein, VILIP protein, HPCAL 3 protein, Visininlike -1 protein, Visininlike -1, Visininlike 1, VSNL1 protein, Visininlike 1 protein, Hippocalcin like protein 3 protein, HUVISL1 protein, VLP-1 protein, HPCAL3 protein