Hepatoma-derived growth factor isoform a, also known as HDGF, belongs to the hepatoma-derived growth factor family. HDGF was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. This nuclear targeted vascular smooth muscle cell mitogen is a heparin-binding protein that is highly expressed in tumor cells where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. Recombinant human HDGF was expressed in E. coli and purified by using conventional chromatography techniques. Alternative Names: HMG1L2 protein, , High mobility group protein 1 like 2 protein, Hepatoma-derived growth factor isoform a Hepatoma derived growth factor protein