Purified recombinant Human BMP7 protein Expression System: CHO cells Bioactivity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 µg/mL.
BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. Alternative Names: BMP 7 protein, BMP7, Bone Morphogenetic protein 7 protein, BMP-7, BMP-7 protein, OP-1 protein, BMP 7, BMP-7 protein