GDF15 Protein

Produktnummer ABIN935652

Produktdetails

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: CHO Cells

Sequenz: ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI

Produktmerkmale: Purified recombinant Human GDF15 protein
Expression System: Cell culture
Bioactivity: Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 µg/mL.

Reinheit: > 98 % pure

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.

Buffer: Lyophilized from 10 mM Sodium Citrate, pH 3.0.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: GDF15 (Growth Differentiation Factor 15 (GDF15))

Andere Bezeichnung: GDF15 (GDF15 Produkte)

Synonyme: GDF15 Protein, GDF-15 Protein, MIC-1 Protein, MIC1 Protein, NAG-1 Protein, PDF Protein, PLAB Protein, PTGFB Protein, SBF Protein, growth differentiation factor 15 Protein, GDF15 Protein, Gdf15 Protein

Hintergrund: GDF-15 belongs to the TGF beta cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
Alternative Names: GDF 15, GDF 15 protein, GDF15, GDF-15 protein, GDF-15, GDF-15 protein, Prostate differentiation factor protein, MIC-1 protein, Placental TGFbeta protein

Pathways: SARS-CoV-2 Protein Interaktom