Purified recombinant Human NP1 protein Expression System: E.coli Bioactivity: Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/mL.
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The a-defensins which include NP-1, NP-2 and NP-3, are distinguished from the beta-defensins by the pairing of their three disulfide bonds. In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells. NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide. NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds. Alternative Names: NP 1 protein, NP 1, Cryptdin protein, alpha Defensin-1 protein, Neutrophil Peptide-1 protein, HNP-1 protein, NP1, NP-1, NP-1 protein, NP-1 protein