Persephin Protein (PSPN)
PSPN
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 98 % pure
Active
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- Target Alle Persephin (PSPN) Proteine anzeigen
- Persephin (PSPN)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Sequenz
- ALSGPCQLWS LTLSVAELGL GYASEEKVIF RYCAGSCPRG ARTQHGLALA RLQGQGRAHG GPCCRPTRYT DVAFLDDRHR WQRLPQLSAA ACGCGG
- Produktmerkmale
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Purified recombinant Human Persephin protein
Expression System: E.coli
Bioactivity: Human Persephin induces RET phosphorylation using a concentration range of 0.1-1.0 ng/mL. Human Persephin binds to mammalian GFRa4 with the Kd of 100 pM. Other members of the GDNF family (Artemin, GDNF and Neurturin) do not bind to mammalian GFRa4. - Reinheit
- > 98 % pure
- Endotoxin-Niveau
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product PSPN Protein
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Persephin (PSPN) (AA 61-156) protein (His tag)
PSPN Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handhabung
- Avoid repeated freeze/thaw cycles.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- Persephin (PSPN)
- Andere Bezeichnung
- Persephin (PSPN Produkte)
- Synonyme
- PSPN Protein, PSP Protein, persephin Protein, PSPN Protein, Pspn Protein
- Hintergrund
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Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons.
Alternative Names: PSP protein, PSPN protein
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