SFRP1 Protein

Produktnummer ABIN935792

Produktdetails

Target: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HeLa Cells

Sequenz: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK

Produktmerkmale: Purified recombinant Human sFRP1 protein
Expression System: HeLa cells
Bioactivity: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5 µg/mL.

Reinheit: > 97 % pure

Endotoxin-Niveau: < 0.1 ng per µg (1 EU/µg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Supplied as a lyophilized powder.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Antigendetails

Target: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Andere Bezeichnung: sFRP1 (SFRP1 Produkte)

Synonyme: FRP Protein, FRP-1 Protein, FRP1 Protein, FrzA Protein, SARP2 Protein, 2210415K03Rik Protein, AW011917 Protein, AW107218 Protein, AW742929 Protein, sFRP-1 Protein, CSFRP1 Protein, SFRP1 Protein, XfrzA Protein, frp Protein, frp-1 Protein, frp1 Protein, frzA Protein, sarp2 Protein, sfrp1 Protein, LOC100231868 Protein, Srfp1a Protein, wu:fd19b09 Protein, secreted frizzled related protein 1 Protein, secreted frizzled-related protein 1 Protein, Secreted frizzled-related protein 1 Protein, secreted frizzled-related protein 1a Protein, secreted frizzled-related protein 1b Protein, SFRP1 Protein, Sfrp1 Protein, sfrp1 Protein, sfrp1a Protein, sfrp1b Protein

Hintergrund: Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas.
Alternative Names: SFRP-1 protein, Secreted Frizzled Related Protein 1 protein, sFRP-1 protein, sFRP 1, sFRP 1 protein, Secreted Apoptosis Related Protein-2 protein, sFRP-1, sFRP1, Soluble Frizzled Related Protein-1 protein, SARP-2 protein

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of fat Cell Differentiation