Purified recombinant Human Thrombopoietin protein Expression System: E.coli Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be 1 x 10^6 units/mg.
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and Mouse TPO exhibits cross-species reactivity. Alternative Names: c-MPL Ligand protein, TPO protein, THPO protein, Megakaryocyte colony-stimulating factor protein, MGDF protein