Defensin beta 4 Protein (DEFB4) (AA 33-47)

Produktnummer ABIN987775

Produktdetails

Target: Defensin beta 4 (DEFB4)

Biologische Aktivität: Active

Proteineigenschaft: AA 33-47

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTK

Produktmerkmale: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay usinghuman monocytes is less than 100 ng/ml, corresponding to a specific activity of >, 1.0 × 104 IU/mg.

Reinheit: > 98 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuBD-4 as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at

Lagerung: 4 °C

Antigendetails

Target: Defensin beta 4 (DEFB4)

Andere Bezeichnung: beta-Defensin 4 (BD-4) (DEFB4 Produkte)

Synonyme: BD-2 Protein, DEFB-2 Protein, DEFB102 Protein, DEFB2 Protein, DEFB4 Protein, HBD-2 Protein, SAP1 Protein, 2310001F05Rik Protein, BD-4 Protein, Defb2 Protein, Defb3 Protein, BNBD-4 Protein, BNBD4 Protein, defensin beta 4A Protein, defensin beta 4 Protein, defensin, beta 4A Protein, DEFB4A Protein, Defb4 Protein

Hintergrund: Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The ª-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Synonym: beta-Defensin 4 ( BD-4 ), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.

Molekulargewicht: Approximately 6.0 KDa, a single non-glycosylated polypeptide chain containing 50 amino acids.