CCL21 Protein

Produktnummer ABIN987838

Produktdetails

Target: CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG

Produktmerkmale: Fully biologically active when compared to standard. The ED50 determined by a chemotaxis bioassay using human peripheral blood T-lymphocytes is less than 600 ng/ml, corresponding to a specific activity of >, 1.7 × 103 IU/mg.

Reinheit: > 97 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuExodus/CCL21 as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: CCL21 (Chemokine (C-C Motif) Ligand 21 (CCL21))

Andere Bezeichnung: Exodus-2/CCL21 (CCL21 Produkte)

Synonyme: 6Ckine Protein, CKb9 Protein, ECL Protein, SCYA21 Protein, SLC Protein, TCA4 Protein, ccl21 Protein, Ccl21b Protein, C-C motif chemokine ligand 21 Protein, C-C motif chemokine 21 Protein, CCL21 Protein, ccl21 Protein, Ccl21 Protein

Hintergrund: Exodus-2/CCL21 is a novel CC chemokine discovered independently by three groups from the EST database, and shows 21-33% identity to other CC chemokines. Exodus-2 contains the four conserved cysteines characteristic of beta chemokines plus two additional cysteines in its unusually long carboxylterminal domain. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Synonym: Exodus-2/CCL21, Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4,150mM NaCl.

Molekulargewicht: 12.2 kDa, a single, non-glycosylated polypeptide chain containing 111 amino acids.

Pathways: Regulation of Actin Filament Polymerization