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IL29 Protein

IL29 Spezies: Human Wirt: Escherichia coli (E. coli) > 97 % by SDS-PAGE and HPLC analyses. Active
Produktnummer ABIN988002
  • Target Alle IL29 Proteine anzeigen
    IL29 (Interleukin 29 (IL29))
    Biologische Aktivität
    Active
    Spezies
    • 12
    • 1
    • 1
    Human
    Quelle
    • 8
    • 4
    • 1
    Escherichia coli (E. coli)
    Sequenz
    GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES
    Produktmerkmale
    Fully biologically active when compared to standard. The ED50 is determined in an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is typically 1-5 ng/ml,corresponding to a specific activity of > 2.0×105 units/mg.
    Reinheit
    > 97 % by SDS-PAGE and HPLC analyses.
    Endotoxin-Niveau
    Level Less than 1EU/µg of rHuIFN-lambda1 as determined by LAL method
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    Discover our top product IL29 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 °C. Further dilutions should be made in appropriate buffered solutions.
    Lagerung
    4 °C
  • Target
    IL29 (Interleukin 29 (IL29))
    Andere Bezeichnung
    Interferon-Lambda1 (IFN-Lambda1) (IL29 Produkte)
    Synonyme
    IL-29 Protein, IL29 Protein, interferon lambda 1 Protein, interferon lambda-1 Protein, interleukin 29 (interferon, lambda 1) Protein, IFNL1 Protein, LOC612539 Protein, IL29 Protein
    Hintergrund
    IL-28A, IL-28B, and IL-29, also named interferon-lambda2 (IFN-lambda2), IFN-lambda3, and IFN-lambda1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and the type I IFN family (15-19% aa sequence identity). The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 Rbeta) and a novel IL-28 receptor alpha (IL-28 Ralpha, also known as IFN-lambdaR1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation. Synonym: Interferon-lambda1 ( IFN-lambda1), Human. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in 20mM PB, pH 7.4, 130mM NaCl.
    Molekulargewicht
    Approximately 19.8 kDa, a single non-glycosylated polypeptide chain containing 181 amino acids.
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