MICB Protein

Produktnummer ABIN988150

Produktdetails

Target: MICB (MHC Class I Polypeptide-Related Sequence B (MICB))

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: ELISA

Produktmerkmale: Measured by its ability to bind MICB antibody in a ELISA.

Reinheit: > 95 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: Level Less than 1EU/µg of rHuMIC-B as determined by LAL method

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20°C. Further dilutions should be made in appropriate buffered solutions.

Lagerung: 4 °C

Antigendetails

Target: MICB (MHC Class I Polypeptide-Related Sequence B (MICB))

Andere Bezeichnung: MIC-B (MICB Produkte)

Synonyme: PERB11.2 Protein, MHC class I polypeptide-related sequence B Protein, MHC class I-related protein-like Protein, MICB Protein, LOC512825 Protein

Hintergrund: MIC-B (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MIC-A, shares 85% amino acid identity with MIC-B. These 2 proteins are distantly related to the MHC class I proteins. MIC-A and MIC-B (MIC-A/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with beta2-microglobulin. The genes encoding MIC-A/B are found within the major histocompatibility complex on human chromosome 6. The MIC-B locus is polymorphic with more than 15 recognized human alleles. MIC-A/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MIC-A/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8+ abeta T cells. Recognition of MIC-A/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MIC-A/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MIC-A/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response. Synonym:. Formulation: Lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4.

Molekulargewicht: Approximately 37 kDa, 326 amino acid residues containing the extracellular domain of mature human MICB (amino acid residues Ala23 – Tyr312).100µg /1000µg

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response