PSMC1 Produkte
(Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1 (PSMC1))
Kategorien
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
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Ausgewählte PSMC1 Kategorien
PSMC1 Antikörper
High quality antibodies with extensive validation data.
PSMC1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PSMC1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p), IF
Validierungen
- (3)
- (3)
Kat. Nr.
ABIN1881692
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN7237615
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (2)
Kat. Nr.
ABIN7442210
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PSMC1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6229234
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PSMC1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7414540
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2729955
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PSMC1 Produkten
: "Global profiling of co- and post-translationally N-myristoylated proteomes in human cells." in: Nature communications, Vol. 5, pp. 4919, (2014) (PubMed).: "A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 38, pp. 13774-9, (2004) (PubMed).
: "Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex." in: Human molecular genetics, Vol. 10, Issue 24, pp. 2821-31, (2001) (PubMed).
: "Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family." in: The Journal of biological chemistry, Vol. 267, Issue 32, pp. 22699-702, (1992) (PubMed).
Synonyme und alternative Namen zu PSMC1
protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1), proteasome 26S subunit, ATPase 1 (PSMC1), proteasome 26S subunit, ATPase 1 (Psmc1), AI325227, P26s4, P26S4, p56, S4, s4Bezeichner auf Proteinebene für PSMC1
- 26S protease regulatory subunit 4
- 26S proteasome AAA-ATPase subunit RPT2
- proteasome 26S subunit ATPase 1
- proteasome 26S ATPase subunit 1
- proteasome 26S subunit, ATPase, 1
- P26s4
- peptidase (prosome, macropain) 26S subunit, ATPase 1
- protease (prosome, macropain) 26S subunit, ATPase 1
- 26S ATPase complex subunit 4
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