PTK2B Produkte
(PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
Kategorien
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte PTK2B Kategorien
PTK2B Antikörper
High quality antibodies with extensive validation data.
PTK2B ELISA Kits
Reliable ELISA kits for a wide range of species.
PTK2B Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PTK2B Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN745763
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, PLA
Validierungen
- (5)
Kat. Nr.
ABIN515514
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IP
Validierungen
- (5)
Kat. Nr.
ABIN560841
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PTK2B ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
- (3)
Kat. Nr.
ABIN1981726
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
- (2)
Kat. Nr.
ABIN2748576
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380820
Menge
2 x 96 tests
Datenblatt
Datenblatt
Empfohlene PTK2B Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316780
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1778387
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5509123
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PTK2B Produkten
: "Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment." in: Cell reports, Vol. 18, Issue 8, pp. 1946-1957, (2017) (PubMed).: "Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis." in: Bone, Vol. 74C, pp. 58-68, (2015) (PubMed).
: "Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2." in: Cancer letters, Vol. 329, Issue 2, pp. 164-73, (2013) (PubMed).
: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).
: "The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5636-44, (2008) (PubMed).
: "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons." in: Journal of cell science, Vol. 120, Issue Pt 17, pp. 3034-44, (2007) (PubMed).
: "Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells." in: Journal of virology, Vol. 80, Issue 3, pp. 1167-80, (2006) (PubMed).
: "The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).
: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, (2004) (PubMed).
"Fresh concepts in dental design." in: Journal of the California Dental Association, Vol. 32, Issue 5, pp. 365-6, (2004) (PubMed).
Synonyme und alternative Namen zu PTK2B
protein tyrosine kinase 2 beta (PTK2B), PTK2 protein tyrosine kinase 2 beta (Ptk2b), protein tyrosine kinase 2 beta (Ptk2b), protein tyrosine kinase 2aa (ptk2aa), CADTK, CAKB, CAKbeta, E430023O05Rik, FADK2, fak1b, FAK2, PKB, PTK, ptk2.2, ptk2b, PYK2, Pyk2, RAFTK, Raftk, si:ch1073-355e8.1Bezeichner auf Proteinebene für PTK2B
- CAK-beta
- FADK 2
- PTK2B protein tyrosine kinase 2 beta
- calcium-dependent tyrosine kinase
- calcium-regulated non-receptor proline-rich tyrosine kinase
- cell adhesion kinase beta
- focal adhesion kinase 2
- proline-rich tyrosine kinase 2
- protein kinase B
- protein-tyrosine kinase 2-beta
- related adhesion focal tyrosine kinase
- cellular adhesion kinase beta
- protein tyrosine kinase 2 beta
- CADTK
- CAK beta
- PTK2 protein tyrosine kinase 2 beta
- fakb
- protein tyrosine kinase 2.2
- protein tyrosine kinase 2aa
- protein tyrosine kinase 2b
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