PTTG1 Produkte
(Pituitary Tumor-Transforming 1 (PTTG1))
Kategorien
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008].
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Ausgewählte PTTG1 Kategorien
PTTG1 Antikörper
High quality antibodies with extensive validation data.
PTTG1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PTTG1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PTTG1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7444319
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF, FACS
Validierungen
- (5)
Kat. Nr.
ABIN6391382
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IHC (p)
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN391532
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene PTTG1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6975309
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN5648205
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PTTG1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124456
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316899
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316901
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PTTG1 Produkten
: "Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis." in: Annals of neurology, Vol. 86, Issue 1, pp. 99-115, (2019) (PubMed).: "Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 6, pp. 414-21, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13." in: Tumour biology, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells." in: Tumour biology, Vol. 35, Issue 9, pp. 8801-11, (2014) (PubMed).
: "PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population." in: The Journal of biological chemistry, Vol. 287, Issue 23, pp. 19516-27, (2012) (PubMed).
Synonyme und alternative Namen zu PTTG1
pituitary tumor-transforming 1 (PTTG1), pituitary tumor-transforming gene 1 (Pttg1), pituitary tumor-transforming 1 (Pttg1), securin, sister chromatid separation inhibitor (cut2), AW555095, C87862, EAP1, HPTTG, Protein Cut2, PTTG, Pttg, PTTG1, Pttg3, securin, Securin, TUTR1Bezeichner auf Proteinebene für PTTG1
- ESP1-associated protein 1
- pituitary tumor-transforming gene 1 protein
- securin
- tumor-transforming protein 1
- pituitary tumor-transforming protein 1
- pituitary tumor-transforming 1
- Pituitary tumor transforming
- Pituitary tumor-transforming gene 1 protein
- Cell untimely torn protein 2
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