RCAN1 Produkte
(Regulator of Calcineurin 1 (RCAN1))
Kategorien
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte RCAN1 Kategorien
RCAN1 Antikörper
High quality antibodies with extensive validation data.
RCAN1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RCAN1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene RCAN1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC
Validierungen
- (7)
Kat. Nr.
ABIN6146811
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN515079
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene RCAN1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959092
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5593142
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Cow
Analytical Method
Validierungen
Kat. Nr.
ABIN2870485
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene RCAN1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1317675
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1317677
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN934952
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren RCAN1 Produkten
: "DSCR1 is required for both axonal growth cone extension and steering." in: The Journal of cell biology, Vol. 213, Issue 4, pp. 451-62, (2017) (PubMed).: "RCAN1 deficiency protects against Salmonella intestinal infection by modulating JNK activation." in: Molecular immunology, Vol. 77, pp. 26-33, (2017) (PubMed).
: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." in: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).
: "Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Targets Down Syndrome Candidate Region 1 (DSCR1/RCAN1) to control Neuronal Differentiation." in: The Journal of biological chemistry, Vol. 290, Issue 34, pp. 21019-31, (2015) (PubMed).
: "Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 24, Issue 1-2, pp. 30-43, (2013) (PubMed).
: "Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 10, pp. 5178-86, (2013) (PubMed).
: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, (2013) (PubMed).
: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).
: "DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis." in: The EMBO journal, Vol. 31, Issue 18, pp. 3655-66, (2012) (PubMed).
: "The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37841-8, (2011) (PubMed).
Synonyme und alternative Namen zu RCAN1
regulator of calcineurin 1 (RCAN1), regulator of calcineurin 1 (Rcan1), regulator of calcineurin 1b (rcan1b), regulator of calcineurin 1 L homeolog (rcan1.L), Down syndrome critical region gene 1 (dscr1), regulator of calcineurin 1 (rcan1), 2410048A02Rik, AA408855, ADAPT78, Adapt78, adapt78, AI429645, AL024459, AV028423, CALP1L, CSP1, csp1, DSC1, dsc1, DSCR1, Dscr1, dscr1, MCIP1, Mcip1, mcip1, MGC53636, MGC69428, RCAN1, rcan1, RCN1, rcn1, wu:fr92c05Bezeichner auf Proteinebene für RCAN1
- Down syndrome candidate region 1
- Down syndrome critical region gene 1
- calcipressin-1
- calcium and oxidant-inducible mRNA
- down syndrome critical region protein 1
- modulatory calcineurin-interacting protein 1
- myocyte-enriched calcineurin-interacting protein 1
- near DSCR proline-rich protein
- calcipressin 1
- down syndrome critical region protein 1 homolog
- regulator of calcineurin 1
- Down syndrome critical region homolog 1
- calcineurin inhibitor
- myocyte-enriched calcineurin interactin protein 1
- Down syndrome critical region protein 1 homolog
- Oxidative-induced protein Adapt78
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