RNF139 Produkte
(Ring Finger Protein 139 (RNF139))
Kategorien
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
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Ausgewählte RNF139 Kategorien
RNF139 Antikörper
High quality antibodies with extensive validation data.
RNF139 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene RNF139 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p)
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN564887
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Bat, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
Applikation
WB, IHC, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN6749727
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (2)
Kat. Nr.
ABIN7151154
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene RNF139 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1318244
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1318242
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren RNF139 Produkten
: "TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation." in: Oncogene, Vol. 32, Issue 18, pp. 2325-34, (2013) (PubMed).: "A meckelin-filamin A interaction mediates ciliogenesis." in: Human molecular genetics, Vol. 21, Issue 6, pp. 1272-86, (2012) (PubMed).
: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).
: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).
: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).
: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." in: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).
Synonyme und alternative Namen zu RNF139
ring finger protein 139 (RNF139), ring finger protein 139 (Rnf139), ring finger protein 139 (rnf139), ring finger protein 139 S homeolog (rnf139.S), 4930555P18Rik, HRCA1, RCA1, rnf139, TRC8, zgc:175173Bezeichner auf Proteinebene für RNF139
- E3 ubiquitin-protein ligase RNF139
- multiple membrane spanning receptor TRC8
- patched related protein translocated in renal cancer
- translocation in renal carcinoma on chromosome 8 protein
- RING finger protein 139
- ring finger protein 139 S homeolog
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