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ROBO3 Produkte

(Roundabout, Axon Guidance Receptor, Homolog 3 (ROBO3))

Kategorien

This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS)\; an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009].

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Ausgewählte ROBO3 Kategorien

ROBO3 Antikörper

High quality antibodies with extensive validation data.

ROBO3 ELISA Kits

Reliable ELISA kits for a wide range of species.

ROBO3 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene ROBO3 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (3)
Kat. Nr. ABIN528582
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, WB
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN190793
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IHC
Validierungen
  • (1)
Kat. Nr. ABIN7168446
Menge 100 μL
Datenblatt Datenblatt

Empfohlene ROBO3 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN4884368
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6384942
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6730276
Menge 96 tests
Datenblatt Datenblatt

Empfohlene ROBO3 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1318429
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Cow, Human, Monkey, Panda
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN2751303
Menge 5 applications
Datenblatt Datenblatt

Neueste Publikationen zu unseren ROBO3 Produkten

Bauer, Dowejko, Bosserhoff, Reichert, Bauer: "Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line." in: Carcinogenesis, Vol. 32, Issue 6, pp. 935-43, (2011) (PubMed).

Kato, Takeuchi, Sato, Yoneyama, Yamamoto, Matsui, Uematsu, Jung, Kawai, Ishii, Yamaguchi, Otsu, Tsujimura, Koh, Reis e Sousa, Matsuura, Fujita, Akira: "Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses." in: Nature, Vol. 441, Issue 7089, pp. 101-5, (2006) (PubMed).

Synonyme und alternative Namen zu ROBO3

roundabout guidance receptor 3 (ROBO3), roundabout 3 (robo3), roundabout guidance receptor 3 (Robo3), robo3 (LOC658818), roundabout guidance receptor 3 L homeolog (robo3.L), roundabout, axon guidance receptor, homolog 3 (Drosophila) (robo3), cb503, CG5423, CG14345, CT17158, DKFZp468G0223, DmelCG5423, dRobo-3, HGPPS, HGPS, RBIG1, Rbig1, Rig-1, RIG1, Rig1, Robo-3, Robo3, ROBO3, robo3, Robo3a, Robo3b

Bezeichner auf Proteinebene für ROBO3

  • retinoblastoma inhibiting gene 1
  • roundabout homolog 3
  • roundabout-like protein 3
  • robo3
  • CG5423-PA
  • robo3-PA
  • roundabout, axon guidance receptor, homolog 3
  • roundabout, axon guidance receptor, homolog 3 (Drosophila)
  • GLEAN_06743
  • roundabout 3
  • roundabout homolog 3-like
  • retinoblastoma-inhibiting gene 1 protein
  • roundabout (axon guidance receptor, Drosophila) homolog 3
  • twi
  • twitch twice
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