RRM2B Produkte
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
Kategorien
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
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Ausgewählte RRM2B Kategorien
RRM2B Antikörper
High quality antibodies with extensive validation data.
RRM2B ELISA Kits
Reliable ELISA kits for a wide range of species.
RRM2B Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene RRM2B Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN565482
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IP
Validierungen
- (2)
Kat. Nr.
ABIN7168147
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IP
Validierungen
- (5)
- (1)
Kat. Nr.
ABIN964915
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene RRM2B ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969961
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951228
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1155811
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene RRM2B Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1318906
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7317292
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3087246
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren RRM2B Produkten
: "Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer." in: American journal of translational research, Vol. 10, Issue 11, pp. 3635-3649, (2018) (PubMed).: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).
: "Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells." in: Oncotarget, Vol. 7, Issue 2, pp. 1984-99, (2016) (PubMed).
: "RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence." in: Scientific reports, Vol. 2, pp. 822, (2013) (PubMed).
: "Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer." in: Cancer research, Vol. 71, Issue 9, pp. 3202-13, (2011) (PubMed).
: "Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells." in: Biochemical and biophysical research communications, Vol. 410, Issue 1, pp. 102-7, (2011) (PubMed).
: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." in: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).
: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).
: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).
: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).
Synonyme und alternative Namen zu RRM2B
ribonucleotide reductase M2 B (TP53 inducible) S homeolog (rrm2b.S), ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), ribonucleotide reductase M2 B (TP53 inducible) (rrm2b), ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), ribonucleotide reductase regulatory TP53 inducible subunit M2B (Rrm2b), MTDPS8A, MTDPS8B, p53r2, P53R2, p53R2, RRM2BBezeichner auf Proteinebene für RRM2B
- ribonucleotide reductase M2 B (TP53 inducible)
- ribonucleoside-diphosphate reductase subunit M2 B
- TP53-inducible ribonucleotide reductase M2 B
- p53-inducible ribonucleotide reductase small subunit 2 homolog
- p53-inducible ribonucleotide reductase small subunit 2 short form beta
- p53-inducible ribonucleotide reductase small subunit 2-like protein
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