Separase Produkte
(Extra Spindle Poles Like 1 (ESPL1))
Kategorien
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
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Ausgewählte Separase Kategorien
Separase Antikörper
High quality antibodies with extensive validation data.
Separase ELISA Kits
Reliable ELISA kits for a wide range of species.
Empfohlene Separase Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC (p)
Validierungen
- (7)
- (3)
Kat. Nr.
ABIN564183
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC (p), DB
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN389654
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
ELISA, IHC, WB
Validierungen
- (3)
Kat. Nr.
ABIN7238939
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene Separase ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380135
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5592033
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Separase Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1353121
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Separase Produkten
: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).
: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).
: "The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib." in: PLoS ONE, Vol. 7, Issue 8, pp. e42863, (2012) (PubMed).
: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).
: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).
: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).
: "Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner." in: Cancer research, Vol. 69, Issue 1, pp. 27-36, (2009) (PubMed).
: "Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner." in: Cell, Vol. 137, Issue 1, pp. 123-32, (2009) (PubMed).
: "Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5446-55, (2008) (PubMed).
Synonyme und alternative Namen zu Separase
extra spindle pole bodies like 1, separase (ESPL1), extra spindle poles like 1 (espl1), extra spindle pole bodies 1, separase (Espl1), extra spindle pole bodies like 1, separase (Espl1), AL024103, AU045071, Cerp, ESP1, mp:zf637-3-001691, PRCE, SEPA, SSEBezeichner auf Proteinebene für Separase
- caspase-like protein ESPL1
- extra spindle poles like 1
- extra spindle poles-like 1 protein
- separin
- separin, cysteine protease
- cds
- separase
- cease&desist
- zf637-3-001691
- Cut1/ESP1 related protein
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