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SETD2 Produkte

(SET Domain Containing 2 (SETD2))

Kategorien

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008].

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Ausgewählte SETD2 Kategorien

SETD2 Antikörper

High quality antibodies with extensive validation data.

Empfohlene SETD2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IF
Validierungen
  • (4)
  • (10)
Kat. Nr. ABIN1682666
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, FACS
Validierungen
  • (4)
Kat. Nr. ABIN7193416
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, FACS
Validierungen
  • (1)
  • (2)
Kat. Nr. ABIN238587
Menge 100 μg
Datenblatt Datenblatt

Empfohlene SETD2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN6205033
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SETD2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (2)
Kat. Nr. ABIN2669625
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Baculovirus
Validierungen
  • (1)
Kat. Nr. ABIN2669663
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SETD2 Produkten

Jia, Miron, Yin, Xu, Luo, Wang, Jia, Wu, Zhang, Li: "HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrCl2 through repressing Setd2." in: Journal of cellular and molecular medicine, Vol. 23, Issue 4, pp. 2667-2677, (2020) (PubMed).

Huang, Gu, Li: "H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation." in: The Journal of biological chemistry, Vol. 293, Issue 20, pp. 7811-7823, (2019) (PubMed).

Jia, Long, Miron, Yin, Wei, Zhang, Wu: "Setd2 is associated with strontium-induced bone regeneration." in: Acta biomaterialia, Vol. 53, pp. 495-505, (2018) (PubMed).

Chen, Liu, Liu, Xia, Zhang, Han, Jiang, Wang, Cao: "Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity." in: Cell, Vol. 170, Issue 3, pp. 492-506.e14, (2017) (PubMed).

Zhu, Lei, Ju, Wang, Huang, Yang, Shao, Zhu, Wei, Fu, Li, Wu: "SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing." in: Nucleic acids research, Vol. 45, Issue 1, pp. 92-105, (2017) (PubMed).

Yi, Tao, Lin, Dai, Yang, Yue, Jiang, Li, Jiang, Andrade, Chang: "Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts." in: Biochimica et biophysica acta. Molecular cell research, Vol. 1864, Issue 4, pp. 697-707, (2017) (PubMed).

Kanu, Grönroos, Martinez, Burrell, Yi Goh, Bartkova, Maya-Mendoza, Mistrík, Rowan, Patel, Rabinowitz, East, Wilson, Santos, McGranahan, Gulati, Gerlinger, Birkbak, Joshi, Alexandrov, Stratton, Powles et al.: "SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. ..." in: Oncogene, Vol. 34, Issue 46, pp. 5699-708, (2015) (PubMed).

Barrand, Andersen, Collas: "Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes." in: Biochemical and biophysical research communications, Vol. 401, Issue 4, pp. 611-7, (2010) (PubMed).

Müller, Rieder, Karpova, John, Trajanoski, McNally: "Organization of chromatin and histone modifications at a transcription site." in: The Journal of cell biology, Vol. 177, Issue 6, pp. 957-67, (2007) (PubMed).

Sun, Wei, Wu, Hu, Wang, Wang, Zhang, Chen, Huang, Chen: "Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase." in: The Journal of biological chemistry, Vol. 280, Issue 42, pp. 35261-71, (2005) (PubMed).

Synonyme und alternative Namen zu SETD2

SET domain containing 2 (Setd2), SET domain containing 2 (SETD2), HBP231, HIF-1, HIP-1, HYPB, Kif9, KMT3A, p231HBP, SET2

Bezeichner auf Proteinebene für SETD2

  • histone-lysine N-methyltransferase SETD2
  • kinesin family member 9
  • huntingtin interacting protein 1
  • huntingtin yeast partner B
  • huntingtin-interacting protein B
  • lysine N-methyltransferase 3A
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