Maus anti-Human IgA (Free & Bound), (Secretory Component) Antikörper (FITC)

Produktnummer ABIN567757

Produktdetails

Target: IgA

Bindungsspezifität: Free & Bound, Secretory Component

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: FITC

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Produktmerkmale: Molar Ratio: Fluorochrome/IgG: aprox. 2.0

Immunogen: Highly purified Secretory component isolated from Human milk.

Klon: NI 194-4 (A89-039)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Absorption / Emission: 492 nm / 515 nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore by adding 0.5 mL sterile distilled water.

Konzentration: 0.4 mg/mL

Buffer: PBS, pH 7.2 without preservatives and foreign proteins.

Konservierungsmittel: Without preservative

Handhabung: Product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one week or (in aliquots) at -28 °C for longer.

Antigendetails

Target: IgA

Abstract: IgA Produkte

Substanzklasse: Antibody

Hintergrund: Secretory Component Glycoprotein is an epithelial transport receptor for polymeric IgA and IgM. Antibody to secretory component has been shown to be useful for identifying glandular carcinomas. Defects in Secretory Component Glycoprotein are the cause of lipoid proteinosis (LiP), also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane. Examples of positive human tissues: secretory mucosa of gastrointestinal and respiratory tract, epithelia of salivary glands, endometrium, endocervix, kidney, prostate, mammary gland.Synonyms: Human Immunoglobulin A