SIGLEC12 Produkte
(Sialic Acid Binding Ig-Like Lectin 12 (SIGLEC12))
Kategorien
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte SIGLEC12 Kategorien
SIGLEC12 Antikörper
High quality antibodies with extensive validation data.
SIGLEC12 ELISA Kits
Reliable ELISA kits for a wide range of species.
SIGLEC12 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SIGLEC12 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (3)
Kat. Nr.
ABIN529939
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, IHC, IP, ICC
Validierungen
- (2)
Kat. Nr.
ABIN7437041
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, ELISA
Validierungen
- (1)
Kat. Nr.
ABIN7169557
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene SIGLEC12 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN511596
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rabbit
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN775684
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Guinea Pig
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN777649
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SIGLEC12 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1319985
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7400804
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7404062
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SIGLEC12 Produkten
: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).: "Identification and characterization of S2V, a novel putative siglec that contains two V set Ig-like domains and recruits protein-tyrosine phosphatases SHPs." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23816-24, (2001) (PubMed).
: "A second uniquely human mutation affecting sialic acid biology." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 40282-7, (2001) (PubMed).
Synonyme und alternative Namen zu SIGLEC12
sialic acid binding Ig like lectin 12 (gene/pseudogene) (SIGLEC12), sialic acid binding Ig like lectin 12 (SIGLEC12), sialic acid binding Ig-like lectin 12 (SIGLEC12), S2V, Siglec-XII, SIGLECL1, SLGBezeichner auf Proteinebene für SIGLEC12
- SIGLEC-like 1
- sialic acid-binding Ig-like lectin 12
- sialic acid-binding Ig-like lectin-like 1
- sialic acid binding immunoglobulin-like lectin-like protein 1
- sialic acid-binding lectin Siglec-L1
- siglec-12
- siglec-L1
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