SLC12A3 Produkte
(Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3))
Kategorien
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte SLC12A3 Kategorien
SLC12A3 Antikörper
High quality antibodies with extensive validation data.
SLC12A3 ELISA Kits
Reliable ELISA kits for a wide range of species.
SLC12A3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SLC12A3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Rat
Applikation
WB, IHC, ICC, IEM, IF
Validierungen
- (10)
- (7)
Kat. Nr.
ABIN863201
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ICC, IP
Validierungen
- (9)
Kat. Nr.
ABIN7435784
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ICC, IP
Validierungen
- (8)
Kat. Nr.
ABIN7441745
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene SLC12A3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (5)
Kat. Nr.
ABIN6720503
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5657169
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SLC12A3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7401062
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7397996
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3113965
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SLC12A3 Produkten
: "Generating Multiple Kidney Progenitors and Cell Types from Human Pluripotent Stem Cells." in: Methods in molecular biology (Clifton, N.J.), Vol. 1926, pp. 103-115, (2019) (PubMed).: "A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation." in: Circulation research, Vol. 125, Issue 12, pp. 1055-1066, (2019) (PubMed).
: "Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule." in: Hypertension (Dallas, Tex. : 1979), Vol. 73, Issue 1, pp. 112-120, (2019) (PubMed).
: "Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis." in: Kidney international, Vol. 92, Issue 2, pp. 397-414, (2018) (PubMed).
: "β3 adrenergic receptor in the kidney may be a new player in sympathetic regulation of renal function." in: Kidney international, Vol. 90, Issue 3, pp. 555-67, (2017) (PubMed).
: "Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys." in: Journal of extracellular vesicles, Vol. 5, pp. 29642, (2016) (PubMed).
: "The Role of Epithelial Sodium Channel ENaC and the Apical Cl-/HCO3- Exchanger Pendrin in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation." in: PLoS ONE, Vol. 11, Issue 3, pp. e0150918, (2016) (PubMed).
: "Tenofovir during pregnancy in rats: a novel pathway for programmed hypertension in the offspring." in: The Journal of antimicrobial chemotherapy, Vol. 70, Issue 4, pp. 1094-105, (2015) (PubMed).
: "Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency." in: Hypertension, Vol. 66, Issue 1, pp. 68-74, (2015) (PubMed).
: "A Systems Level Analysis of Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells." in: Scientific reports, Vol. 5, pp. 12829, (2015) (PubMed).
Synonyme und alternative Namen zu SLC12A3
solute carrier family 12 member 3 (SLC12A3), solute carrier family 12 (sodium/chloride transporter), member 3 (slc12a3.2), solute carrier family 12 member 3 (Slc12a3), solute carrier family 12, member 3 (Slc12a3), AI035291, DKFZp469N2315, NCC, NCCT, SLC12A3, slc12a3, TSCBezeichner auf Proteinebene für SLC12A3
- solute carrier family 12 (sodium/chloride transporters), member 3
- thiazide-sensitive sodium chloride cotransporter
- solute carrier family 12 (sodium/chloride transporters), member 3, gene 2
- solute carrier family 12 member 3-like
- Na-Cl cotransporter
- Na-Cl symporter
- NaCl electroneutral thiazide-sensitive cotransporter
- solute carrier family 12 member 3
- thiazide-sensitive Na-Cl cotransporter
- thiazide-sensitive sodium-chloride cotransporter
- solute carrier family 12, member 3
- sodium chloride cotransporter
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