Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SMN2 Produkte

(Survival of Motor Neuron 2, Centromeric (SMN2))

Kategorien

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008].

antibodies-online.com steht für hochwertige Forschungsprodukte. Suchen, finden und bestellen Sie Tools mit umfangreichen Validierungsdaten, Bildern, Referenzen. Unser wissenschaftlicher Kundenservice steht Ihnen jederzeit zur Verfügung, wenn Sie Fragen zur Auswahl oder Anwendung unserer Produkte haben.

Ausgewählte SMN2 Kategorien

SMN2 Antikörper

High quality antibodies with extensive validation data.

SMN2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SMN2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene SMN2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IF, ELISA, IHC (p)
Validierungen
  • (6)
Kat. Nr. ABIN948481
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (5)
Kat. Nr. ABIN7435538
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF, IP
Validierungen
  • (4)
Kat. Nr. ABIN6148134
Menge 100 μL
Datenblatt Datenblatt

Empfohlene SMN2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6959786
Menge 96 tests
Datenblatt Datenblatt

Empfohlene SMN2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
  • (1)
Kat. Nr. ABIN1320680
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1320682
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7397549
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren SMN2 Produkten

Cucchiarini, Madry, Terwilliger: "Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis." in: Journal of cellular and molecular medicine, Vol. 18, Issue 1, pp. 115-24, (2013) (PubMed).

Synonyme und alternative Namen zu SMN2

survival of motor neuron 2, centromeric (SMN2), survival of motor neuron 2, centromeric L homeolog (smn2.L), BCD541, bcd541, C-BCD541, c-bcd541, gemin-1, GEMIN1, smn2, SMNC, smnc, TDRD16B

Bezeichner auf Proteinebene für SMN2

  • component of gems 1
  • gemin-1
  • survival motor neuron protein
  • tudor domain containing 16B
  • gemin 1
  • survival of motor neuron 2, centromeric L homeolog
Sie sind hier:
Kundenservice