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STAT2 Produkte

(Signal Transducer and Activator of Transcription 2, 113kDa (STAT2))
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].

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Ausgewählte STAT2 Kategorien

STAT2 Antikörper

High quality antibodies with extensive validation data.

STAT2 ELISA Kits

Reliable ELISA kits for a wide range of species.

STAT2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene STAT2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (7)
Kat. Nr. ABIN7434083
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Rat
Applikation WB, IHC, IP, ICC
Validierungen
  • (7)
Kat. Nr. ABIN7443368
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validierungen
  • (6)
Kat. Nr. ABIN738246
Menge 100 μL
Datenblatt Datenblatt

Empfohlene STAT2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validierungen
  • (3)
Kat. Nr. ABIN5691024
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970214
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Mouse
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970213
Menge 96 tests
Datenblatt Datenblatt

Empfohlene STAT2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1321592
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7394858
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Mouse
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7406047
Menge 100 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren STAT2 Produkten

Yamauchi, Takeuchi, Chihara, Honjoh, Kato, Yoshiki, Hotta, Sada: "STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α." in: Scientific reports, Vol. 6, pp. 38336, (2018) (PubMed).

Zhu, Wang, Zhou, Pan, Chen, Yang, Lv, Ye, Peng, Fang, Xiao: "Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2." in: Journal of virology, Vol. 91, Issue 10, (2017) (PubMed).

Alves de Medeiros, Speeckaert, Desmet, Van Gele, De Schepper, Lambert: "JAK3 as an Emerging Target for Topical Treatment of Inflammatory Skin Diseases." in: PloS one, Vol. 11, Issue 10, pp. e0164080, (2017) (PubMed).

Thacker, Berthier, Mattinzoli, Rastaldi, Kretzler, Kaplan: "The detrimental effects of IFN-α on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4457-69, (2010) (PubMed).

Dolniak, Katsoulidis, Carayol, Altman, Redig, Tallman, Ueda, Watanabe-Fukunaga, Fukunaga, Platanias: "Regulation of arsenic trioxide-induced cellular responses by Mnk1 and Mnk2." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12034-42, (2008) (PubMed).

Katsoulidis, Sassano, Majchrzak-Kita, Carayol, Yoon, Jordan, Druker, Fish, Platanias: "Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells." in: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10793-803, (2008) (PubMed).

Jaitin, Schreiber: "Upregulation of a small subset of genes drives type I interferon-induced antiviral memory." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 27, Issue 8, pp. 653-64, (2007) (PubMed).

Brierley, Fish: "Stats: multifaceted regulators of transcription." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 25, Issue 12, pp. 733-44, (2005) (PubMed).

Brierley, Fish: "Functional relevance of the conserved DNA-binding domain of STAT2." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 13029-36, (2005) (PubMed).

Banninger, Reich: "STAT2 nuclear trafficking." in: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39199-206, (2004) (PubMed).

Synonyme und alternative Namen zu STAT2

signal transducer and activator of transcription 2 (stat2), signal transducer and activator of transcription 2 (STAT2), AGAP000099-PA (STAT2), signal transducer and activator of transcription 2 (Stat2), 1600010G07Rik, AW496480, ISGF-3, p113, P113, stat2, STAT113, wu:fj84d07

Bezeichner auf Proteinebene für STAT2

  • fj84d07
  • signal transducer and activator of transcription 2
  • signal transducer and activator of transcription (AGAP000099-PA)
  • interferon alpha induced transcriptional activator
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