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STING/TMEM173 Produkte

(Transmembrane Protein 173 (TMEM173))
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

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Ausgewählte STING/TMEM173 Kategorien

STING/TMEM173 Antikörper

High quality antibodies with extensive validation data.

STING/TMEM173 ELISA Kits

Reliable ELISA kits for a wide range of species.

STING/TMEM173 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene STING/TMEM173 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, ICC
Validierungen
  • (6)
Kat. Nr. ABIN7439447
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IP, IF
Validierungen
  • (8)
Kat. Nr. ABIN6220283
Menge 20 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IHC, IHC (p)
Validierungen
  • (9)
Kat. Nr. ABIN1501428
Menge 100 μL
Datenblatt Datenblatt

Empfohlene STING/TMEM173 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6970832
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6960146
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6999504
Menge 96 tests
Datenblatt Datenblatt

Empfohlene STING/TMEM173 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7125482
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN7092708
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN6573465
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren STING/TMEM173 Produkten

Zhang, Wei, Cui, Hong, Liu, Wang, Li, Liu, Yu, Cai, Wang, Zhu, Meng, Chen, Wang: "The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway." in: PLoS pathogens, Vol. 14, Issue 11, pp. e1007435, (2019) (PubMed).

Gentili, Lahaye, Nadalin, Nader, Puig Lombardi, Herve, De Silva, Rookhuizen, Zueva, Goudot, Maurin, Bochnakian, Amigorena, Piel, Fachinetti, Londoño-Vallejo, Manel: "The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus." in: Cell reports, Vol. 26, Issue 9, pp. 2377-2393.e13, (2019) (PubMed).

Yang, Lee, Kong, Kim, Kim, Chang, Kim, Kim, Chon, Kim: "STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade." in: The Journal of clinical investigation, Vol. 130, pp. 4350-4364, (2019) (PubMed).

Gaston, Cheradame, Yvonnet, Deas, Poupon, Judde, Cairo, Goffin: "Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents." in: Oncotarget, Vol. 7, Issue 47, pp. 77205-77224, (2018) (PubMed).

Choi, Park, Kang, Lee, Lee, Ra, Lee, Lee, Park: "Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses." in: Nature communications, Vol. 9, Issue 1, pp. 125, (2018) (PubMed).

Albertini, Lo Cigno, Calati, De Andrea, Borgogna, DellOste, Landolfo, Gariglio: "HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-β and IFN-λ1 Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 6, pp. 2076-2089, (2018) (PubMed).

Ghosh, Roy, Franco: "PARP1 depletion induces RIG-I-dependent signaling in human cancer cells." in: PLoS ONE, Vol. 13, Issue 3, pp. e0194611, (2018) (PubMed).

Yang, Wang, Ketkar, Ma, Yang, Cui, Geng, Mordue, Fujimoto, Cheng, You, Lin, Fikrig, Wang: "UBXN3B positively regulates STING-mediated antiviral immune responses." in: Nature communications, Vol. 9, Issue 1, pp. 2329, (2018) (PubMed).

Bhattacharya, Srinivasan, Abdisalaam, Su, Raj, Dozmorov, Mishra, Wakeland, Ghose, Mukherjee, Asaithamby: "RAD51 interconnects between DNA replication, DNA repair and immunity." in: Nucleic acids research, Vol. 45, Issue 8, pp. 4590-4605, (2017) (PubMed).

Chen, Shen, Hsia, Tiang, Sung, Chen: "Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway." in: Nature structural & molecular biology, Vol. 24, Issue 12, pp. 1124-1131, (2017) (PubMed).

Synonyme und alternative Namen zu STING/TMEM173

transmembrane protein 173 (TMEM173), transmembrane protein 173 (Tmem173), 2610307O08Rik, ERIS, MITA, Mita, MPYS, NET23, RGD1562552, STING

Bezeichner auf Proteinebene für STING/TMEM173

  • transmembrane protein 173
  • N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
  • STING1
  • endoplasmic reticulum IFN stimulator
  • endoplasmic reticulum interferon stimulator
  • hMITA
  • hSTING
  • mediator of IRF3 activation
  • mitochondrial mediator of IRF3 activation
  • stimulator of interferon genes protein
  • MMITA
  • mSTING
  • Stimulator of interferon genes protein
  • mitochondrial transmembrane protein 173
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