SUPT5H Produkte
(Transcription Elongation Factor SPT5 (SUPT5H))
Kategorien
Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.
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Ausgewählte SUPT5H Kategorien
SUPT5H Antikörper
High quality antibodies with extensive validation data.
SUPT5H ELISA Kits
Reliable ELISA kits for a wide range of species.
SUPT5H Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene SUPT5H Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC (p)
Validierungen
- (4)
Kat. Nr.
ABIN520620
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Applikation
WB, IHC, IHC (p)
Validierungen
- (3)
Kat. Nr.
ABIN6735860
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Zebrafish (Danio rerio)
Applikation
WB, IHC
Validierungen
- (4)
Kat. Nr.
ABIN2777903
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene SUPT5H ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1162213
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1162214
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Chicken
Analytical Method
Validierungen
Kat. Nr.
ABIN1162212
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene SUPT5H Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1321917
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3131899
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3095662
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren SUPT5H Produkten
: "Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism." in: eLife, Vol. 4, pp. e06535, (2015) (PubMed).: "Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway." in: Nature communications, Vol. 3, pp. 976, (2012) (PubMed).
: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).
: "Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice." in: Cell, Vol. 128, Issue 1, pp. 71-83, (2007) (PubMed).
: "Differential regulation of NF-kappaB by elongation factors is determined by core promoter type." in: Molecular and cellular biology, Vol. 27, Issue 14, pp. 5246-59, (2007) (PubMed).
Synonyme und alternative Namen zu SUPT5H
SPT5 homolog, DSIF elongation factor subunit (SUPT5H), transcription elongation factor SPT5 (LOC413814), Transcription elongation factor Spt5 (AT2G34210), transcription elongation factor Spt5 (spt5), transcription elongation factor spt5 (MGYG_08422), transcription elongation factor spt5 (TERG_05483), hypothetical protein (PGTG_18458), SPT5 homolog, DSIF elongation factor subunit (supt5h), SPT5 homolog, DSIF elongation factor subunit (Supt5h), SPT5 homolog, DSIF elongation factor subunit S homeolog (supt5h.S), CG7626 gene product from transcript CG7626-RA (Spt5), Transcription elongation factor SPT5 (spt-5), transcription elongation factor (SPT5), CaO19.1453, CG7626, dDSIF, Dmel\\CG7626, DSIF, Dspt5, dSpt5, etID10129.15, etID37101.15, F13P17.5, F13P17_5, fb37g01, fb95e05, fog, foggy, SPT5, Spt5, spt5, SPT5H, spt5h, Tat-CT1, tat-ct1, wu:fb37g01, wu:fb95e05, wu:fc10f02Bezeichner auf Proteinebene für SUPT5H
- DRB sensitivity-inducing factor 160 kDa subunit
- DRB sensitivity-inducing factor large subunit
- DSIF large subunit
- DSIF p160
- Tat-cotransactivator 1 protein
- hSPT5
- transcription elongation factor SPT5
- transcription elongation factor Spt5
- transcription elongation factor spt5
- protein foggy
- transcription elongation regulator foggy
- CG7626-PA
- Spt5-PA
- Chromatin elongation factor SPT5
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