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TAF4 Produkte

(TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008].

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Ausgewählte TAF4 Kategorien

TAF4 Antikörper

High quality antibodies with extensive validation data.

TAF4 ELISA Kits

Reliable ELISA kits for a wide range of species.

TAF4 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene TAF4 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, IHC (p)
Validierungen
  • (3)
Kat. Nr. ABIN6244013
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, ELISA, IF, ICC
Validierungen
  • (3)
Kat. Nr. ABIN6265437
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, IF
Validierungen
  • (4)
  • (3)
Kat. Nr. ABIN968728
Menge 50 μg
Datenblatt Datenblatt

Empfohlene TAF4 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse
Analytical Method Qualitative Cell ELISA
Validierungen
Kat. Nr. ABIN5648297
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
Kat. Nr. ABIN511631
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Chicken
Analytical Method Quantitative
Validierungen
Kat. Nr. ABIN1059016
Menge 96 tests
Datenblatt Datenblatt

Empfohlene TAF4 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1322093
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3095791
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Candida albicans
Source Yeast
Validierungen
Kat. Nr. ABIN1631845
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren TAF4 Produkten

Freiman, Albright, Chu, Zheng, Liang, Sha, Tjian: "Redundant role of tissue-selective TAF(II)105 in B lymphocytes." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6564-72, (2002) (PubMed).

Shimohata, Nakajima, Yamada, Uchida, Onodera, Naruse, Kimura, Koide, Nozaki, Sano, Ishiguro, Sakoe, Ooshima, Sato, Ikeuchi, Oyake, Sato, Aoyagi, Hozumi, Nagatsu, Takiyama, Nishizawa, Goto, Kanazawa et al.: "Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. ..." in: Nature genetics, Vol. 26, Issue 1, pp. 29-36, (2000) (PubMed).

Saluja, Vassallo, Tanese: "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators." in: Molecular and cellular biology, Vol. 18, Issue 10, pp. 5734-43, (1998) (PubMed).

Mengus, May, Carré, Chambon, Davidson: "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells." in: Genes & development, Vol. 11, Issue 11, pp. 1381-95, (1997) (PubMed).

Synonyme und alternative Namen zu TAF4

TBP-associated factor 4 (Taf4), Taf4p (TAF4), TATA-box binding protein associated factor 4 (TAF4), TATA-box binding protein associated factor 4 L homeolog (taf4.L), CG5444, d110, Dmel\\CG5444, dmTAF4, dTAF4, dTAFII110, dTAF[[II]]110, l(3)72Dj, p110, SR3-3, SY3-2 TAF110, TAF, TAF2C, TAF2C1, TAF4, TAF4A, TAF110, Taf110, taf110, TAFII110, TAFII130, TAFII135, TAF[II]110, TAF[[II]], TAF[[II]]110, Taf[[II]]110, TFIID, TFIID 110

Bezeichner auf Proteinebene für TAF4

  • CG5444-PA
  • CG5444-PB
  • CG5444-PC
  • CG5444-PD
  • CG5444-PE
  • CG5444-PF
  • CG5444-PG
  • CG5444-PH
  • TATA-associated factor 110
  • TBP associated factor 110
  • TBP-associated factor
  • TBP-associated factor 110
  • TBP-associated factor 110kD
  • Taf4-PA
  • Taf4-PB
  • Taf4-PC
  • Taf4-PD
  • Taf4-PE
  • Taf4-PF
  • Taf4-PG
  • Taf4-PH
  • lethal(3)72Dj
  • hypothetical protein
  • RNA polymerase II TBP-associated factor subunit C
  • TAF(II)130
  • TAF(II)135
  • TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD
  • TAFII-130
  • TAFII-135
  • TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD
  • TBP-associated factor 4
  • transcription initiation factor TFIID 130 kDa subunit
  • transcription initiation factor TFIID 135 kD subunit
  • transcription initiation factor TFIID 135 kDa subunit
  • transcription initiation factor TFIID subunit 4
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