TBP Produkte
(TATA Box Binding Protein (TBP))
Kategorien
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010].
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Ausgewählte TBP Kategorien
TBP Antikörper
High quality antibodies with extensive validation data.
TBP ELISA Kits
Reliable ELISA kits for a wide range of species.
TBP Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TBP Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, ICC, FACS
Validierungen
- (8)
Kat. Nr.
ABIN7193395
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, IF, FACS
Validierungen
- (6)
Kat. Nr.
ABIN3029099
Menge
0.4 mL
Datenblatt
Datenblatt
Reaktivität
Human, Monkey, Mouse, Rat
Applikation
WB, ELISA, IHC (p)
Validierungen
- (8)
Kat. Nr.
ABIN3029100
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene TBP ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN511633
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Chicken
Analytical Method
Quantitative
Validierungen
Kat. Nr.
ABIN1059007
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Monkey
Analytical Method
Quantitative
Validierungen
Kat. Nr.
ABIN1059008
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TBP Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322267
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7420309
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7413751
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TBP Produkten
: "Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 303, Issue 6, pp. L519-27, (2012) (PubMed).: "Identification of novel functional TBP-binding sites and general factor repertoires." in: The EMBO journal, Vol. 26, Issue 4, pp. 944-54, (2007) (PubMed).
: "Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction." in: PLoS biology, Vol. 4, Issue 3, pp. e67, (2006) (PubMed).
: "HIV-1 Tat stimulates transcription complex assembly through recruitment of TBP in the absence of TAFs." in: PLoS biology, Vol. 3, Issue 2, pp. e44, (2005) (PubMed).
: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." in: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).
: "Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids." in: Development (Cambridge, England), Vol. 129, Issue 4, pp. 945-55, (2002) (PubMed).
: "Distinct TFIID complexes mediate the effect of different transcriptional activators." in: The EMBO journal, Vol. 12, Issue 2, pp. 489-99, (1993) (PubMed).
: "Highly conserved core domain and unique N terminus with presumptive regulatory motifs in a human TATA factor (TFIID)." in: Nature, Vol. 346, Issue 6282, pp. 387-90, (1990) (PubMed).
: "Functional domains and upstream activation properties of cloned human TATA binding protein." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1625-30, (1990) (PubMed).
: "Cloning of a transcriptionally active human TATA binding factor." in: Science (New York, N.Y.), Vol. 248, Issue 4963, pp. 1646-50, (1990) (PubMed).
Synonyme und alternative Namen zu TBP
TATA-box binding protein (TBP), TATA box binding protein (Tbp), TATA box binding protein (tbp), TATA box binding protein (TBP), TATA-box binding protein (tbp), TATA binding protein (Tbp), TATA-box binding protein L homeolog (tbp.L), TATA-box binding protein (Tbp), TATA-box-binding protein (Tbp), TATA-box binding protein S homeolog (tbp.S), CG9874, Dmel\\CG9874, dTBP, dTbp, dtbp, dTFIID, fd20h06, GTF2D, Gtf2d, gtf2d, GTF2D1, gtf2d1, HDL4, RBP, SCA17, sca17, si:zc101n13.2, TBP, tbp, tbp-a, tbp-b, TBP1, TBP38, TFIID, TfIID, tfiid, TFIIDtau, tfiidtau, wu:fd20h06, xtbp, zgc:66213Bezeichner auf Proteinebene für TBP
- TATA sequence-binding protein
- TATA-box binding protein N-terminal domain
- TATA-box factor
- TATA-box-binding protein
- transcription initiation factor TFIID TBP subunit
- TATA-binding factor
- TATA-binding protein
- TFIID core protein
- zTBP
- zfTBF
- TA-TA binding protein 1
- TATA binding protein
- TATA box binding protein
- 42kDa polypeptide
- CG9874-PA
- TATA box-binding protein
- TATA-box binding protein
- Tbp-PA
- transcription factor
- Transcription initiation factor TFIID TBP subunit
- TATA-box binding protein S homeolog
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