TCF3 Produkte
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
Kategorien
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1\;19), with PBX1), childhood leukemia (t(19\;19), with TFPT) and acute leukemia (t(12\;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011].
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Ausgewählte TCF3 Kategorien
TCF3 Antikörper
High quality antibodies with extensive validation data.
TCF3 ELISA Kits
Reliable ELISA kits for a wide range of species.
TCF3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene TCF3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS, IHC (p)
Validierungen
- (5)
Kat. Nr.
ABIN657912
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA
Validierungen
- (1)
- (3)
Kat. Nr.
ABIN563112
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, FACS
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN1724729
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene TCF3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6970767
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN5661964
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Validierungen
Kat. Nr.
ABIN1162300
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene TCF3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1322367
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7422253
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3133067
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren TCF3 Produkten
: "Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression." in: Molecular and cellular biochemistry, Vol. 389, Issue 1-2, pp. 151-8, (2014) (PubMed).: "T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor ?B signaling." in: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17552-8, (2013) (PubMed).
: "Synaptic cross-talk between N-methyl-D-aspartate receptors and LAPSER1-beta-catenin at excitatory synapses." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 29146-57, (2009) (PubMed).
: "Accelerated Notch-dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3521-9, (2007) (PubMed).
: "Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 45028-35, (2004) (PubMed).
: "Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO." in: Developmental cell, Vol. 7, Issue 6, pp. 843-54, (2004) (PubMed).
: "Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities." in: The EMBO journal, Vol. 22, Issue 21, pp. 5780-92, (2003) (PubMed).
: "Inhibition of Tcf3 binding by I-mfa domain proteins." in: Molecular and cellular biology, Vol. 21, Issue 5, pp. 1866-73, (2001) (PubMed).
: "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function." in: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33567-73, (2000) (PubMed).
: "Both E12 and E47 allow commitment to the B cell lineage." in: Immunity, Vol. 6, Issue 2, pp. 145-54, (1997) (PubMed).
Synonyme und alternative Namen zu TCF3
transcription factor 3 (TCF3), transcription factor 3b (tcf3b), transcription factor 3 (Tcf3), transcription factor 3 L homeolog (tcf3.L), transcription factor E2a (tcfe2a), A1, AA408400, ALF2, AW209082, bHLHb21, bhlhb21, E2A, e2a, E12, E12/E47, E47, G12, ITF1, itf1, ME2, Pan1, Pan2, TCF-3, tcf3a, TCF7L1, Tcfe2a, tcfe2a, VDIR, vdir, XE3, xtcf-3, xtcf3, zgc:113045Bezeichner auf Proteinebene für TCF3
- VDR interacting repressor
- class B basic helix-loop-helix protein 21
- helix-loop-helix protein HE47
- immunoglobulin transcription factor 1
- kappa-E2-binding factor
- negative vitamin D response element-binding protein
- transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
- transcription factor E2-alpha
- transcription factor ITF-1
- vitamin D receptor-interacting repressor
- transcription factor 3
- TCF-3
- immunoglobulin enhancer-binding factor E12/E47
- transcription factor A1
- transcription factor E2a
- pancreas specific transcription factor 1c
- transcription regulator Pan
- transcription factor XE12/XE47
- class A basic helix-loop-helix transcription factor G12
- helix-loop-helix protein E12
- helix-loop-helix protein E47
- transcription factor 7-like 1 (T-cell specific, HMG-box)
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